The cancer treatment with chemotherapy drugs is often accompanied by delayed neurological complications, which greatly impairs the quality of life of patients cured of cancer.
According to a new study, treatment by 5 - FU in mono enough for the emergence of the central nervous system (CNS) deferred degeneration.
5-FU is widely used to treat cancer diseases both independently and in combination with other chemotherapy drugs. About the side effects of chemotherapy on the central nervous system is known very little, in spite of great clinical significance of this problem.
Until now, scientists do not fully understand all the mechanisms occurrence of this complication.
Professor Mark Nobel and the sponsors of the Harvard School of Medicine, Boston, USA found, that the appointment system 5 - FU in the mice leads to severe damage of central nervous system, as well as to the syndrome of progressive damage delayed. This defeat is not restored independently, but only progressing with the times.
Myelin sheath is essential for the normal functioning of nerve fibers. It turned out that 5 - FU has a toxic effect not only on fissile cells, but also on cells that are responsible for the synthesis of myelin.
This study confirms the possibility of treating stem cells, which can contribute to transplantation myelin regeneration and nervous tissue.
This is the first study, which demonstrated that a deferred neurotoxicity can cause even one chemotherapy drug, and for the first time such a defeat of CNS was modeled on animals.
May 14
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